COMBINATIONS OF ANTIBODIES TO STAPHYLOCOCCUS AUREUS Russian patent published in 2023 - IPC A61K39/40 C07K16/12 A61P31/04 

FIELD: pharmaceuticals; medicine.

SUBSTANCE: objects 1 and 2 are the methods of treating or preventing a Staphylococcus aureus (S. aureus) infection in an individual, comprising administering to the individual an antibody or antigen-binding fragment thereof that binds to at least one S. aureus leukotoxin, and the antibody or antigen-binding fragment thereof that bind to S. aureus alpha toxin (AT), and/or an antibody or antigen-binding fragment thereof that bind to S. aureus clumping factor A (ClfA). objects 3 and 4 objects are compositions for the treatment or prevention of infection caused by S. aureus in an individual, containing the above antibodies. objects 5–7 — the use of one of the above antibodies or their antigen-binding fragments for the preparation of a drug for the treatment or prevention of infection caused by S. aureus in an individual, in combination with other antibodies above.

EFFECT: technical result is to provide a wide coverage of strains for the treatment or prevention of infection caused by S. aureus in an individual, a combination of antibodies that target several different bacterial virulence factors through a complementary mechanism of action.

87 cl, 17 dwg, 7 tbl, 11 ex