FIELD: medicine.
SUBSTANCE: invention relates to the use of an inhibitor of T-cell co-stimulation and/or activation for the treatment or prevention of heart failure induced by pressure overload. The specified inhibitor contains an extracellular domain CTLA4 or its functional derivative, which binds CD80 and/or CD86. The use of a nucleic acid molecule encoding the specified inhibitor, an expression vector containing nucleic acid, a genetically constructed host cell, which expresses the specified inhibitor, a pharmaceutical composition containing the specified inhibitor or a nucleic acid molecule, or a vector or a host cell for the treatment or prevention of heart failure induced by pressure overload is also proposed.
EFFECT: specified inhibitor, nucleic acid molecule, vector, host cell, and pharmaceutical composition are used in a method for the treatment or prevention of heart failure induced by pressure overload and a method for the treatment or prevention of heart hypertrophy induced by pressure overload and fibrosis.
21 cl, 16 dwg, 3 tbl, 9 ex
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