FIELD: medicine; pharmaceutics.
SUBSTANCE: object 1 is a pharmaceutical composition for preventing or treating a malignant tumour, containing as active ingredients a dimeric fusion protein, containing a variant of IL-2, containing amino acid substitutions R38A and F42A in SEQ ID NO: 10, and an extracellular domain of the CD80 protein, and an immune control point inhibitor, which is selected from a group consisting of an anti-PD-1 antibody, an anti-PD-L1 antibody and an anti-TIGIT antibody. Object 2 is a method of preventing or treating a malignant tumour, comprising administering to an individual having a malignant tumour, a dimeric fusion protein comprising a variant of IL-2, containing amino acid substitutions R38A and F42A in SEQ ID NO: 10, and an extracellular domain of the CD80 protein, and an immune control point inhibitor, which is selected from a group consisting of an anti-PD-1 antibody, an anti-PD-L1 antibody and an anti-TIGIT antibody.
EFFECT: synergetic effect of dimeric fusion protein introduction in combination with immune control point inhibitor.
6 cl, 76 dwg, 8 tbl, 33 ex
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