FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology and is a method of treating a mammal suffering a disease associated with CD19 expression, comprising administering to a mammal an effective amount of a population of mammalian cells containing one or more T-cells or NK-cells which express a CAR molecule that binds to CD19 (CAR19-expressing cells), where the mammal has previously received treatment with ibrutinib. Also disclosed is a method of producing a population of CAR19-expressing cells.
EFFECT: invention makes it possible to effectively treat diseases associated with CD19 expression.
37 cl, 61 dwg, 13 tbl, 16 ex
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