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(19)

(11)

2 781 639

(13)

(51)

IPC

C07D487/04(2006-01-01)

A61K31/4985(2006-01-01)

A61P25/00(2006-01-01)

(21) (22)

Application

2020107163, 2018-08-28

(24)

Start date

2018-08-28

(22)

Actual filing date

2018-08-28

(45)

Published

2022-10-17

(72)

Inventor

Grajs, Sheril A.Veber, Oliviya D.Buzard, Deniel Dzh.Shagkhafaj, Majkl B.Dzhouns, Todd K.

(73)

Holder

Kh. Lundbekk A/S

SPIROCYCLIC COMPOUNDS AND METHODS FOR THEIR PRODUCTION AND USE Russian patent published in 2022 - IPC C07D487/04 A61K31/4985 A61P25/00

Abstract RU 2781639 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to compounds of the formula (II), as well as pharmaceutical compositions based on them.

EFFECT: new compounds are obtained, which can be used as MAGL activity inhibitors.

7 cl, 1 tbl

Title	Year	Author	Number
PYRAZOLE-BASED MAGL INHIBITORS	2018	Grajs, Sheril A. Viner, Dzhon Dzh.M. Veber, Oliviya D. Dunkan Katarina K.	RU2789157C2
MAGL INHIBITORS	2017	Grice, Cheryl A. Buzard, Daniel J. Shaghafi, Michael B.	RU2754536C1
DIHYDROPTERIDINONE DERIVATIVES AND USES THEREOF	2015	Bradner James E. Grey Nathanael Qi Jun Mckeown Michael R. Buckley Dennis	RU2673944C2
CYANOTHIENOTRIAZOLODIAZEPINES AND METHODS FOR THEIR USE	2016	Bradner Dzhejms I. Tsi Tszyun Tanaka Minoru Bakli Dennis	RU2750164C2
BIVALENT BROMODOMAIN INHIBITORS AND ROUTES OF USE THEREOF	2016	Tsi, Tszyun Tanaka, Minoru Roberts, Dzhastin, M. Bradner, Dzhejms I.	RU2742035C2
HETEROCYCLIC SPIRO COMPOUNDS AS MAGL INHIBITORS	2018	Brodney, Michael Aaron Butler, Christopher Ryan Helal, Christopher John Mcallister, Laura Ann O'Neil, Steven Victor Verhoest, Patrick Robert	RU2726631C1
MATRIX METALLOPROTEINASE (MMP) INHIBITORS AND METHODS FOR THEIR APPLICATION	2019	Yang, Wenjin Chang, Kai-Wei Liu, Suying Tsai, Cheng-Han	RU2820540C2
NEW INHIBITOR BASED ON A QUINOLINE DERIVATIVE	2019	Wu, Frank Wan, Zhonghui	RU2802283C2
MATRIX METALLOPROTEINASE (MMP) INHIBITORS AND METHODS OF THEIR APPLICATION	2019	Yang, Wenjin Chang, Kai-Wei Liu, Suying Tsai, Cheng-Han	RU2797558C2
3-(1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND VARIANTS OF THEIR USE	2018	Beckwith, Rohan Eric John Bonazzi, Simone Cernijenko, Artiom Fazal, Aleem Tichkule, Ritesh Bhanudasji Visser, Michael Scott	RU2795850C2

Authors

Grajs, Sheril A.

Veber, Oliviya D.

Buzard, Deniel Dzh.

Shagkhafaj, Majkl B.

Dzhouns, Todd K.

Dates

2022-10-17—Published

2018-08-28—Filed