COMPOUNDS WITH CONDENSED RINGS Russian patent published in 2022 - IPC C07D403/14 C07D487/10 C07D401/14 C07D403/04 A61K31/517 A61P35/00 

FIELD: medicine.

SUBSTANCE: invention relates to a compound of the formula (II) or its pharmaceutically acceptable salt, where R¹ is where each R²⁰ is independently selected from a group consisting of C_1-6 alkyl, halogen, cyclopropyl, and C_1-6 halogenalkyl, and p is 1, 2, or 3; Y¹ is absent; Y² is C(H)(R⁸); Y³ is CH; Z¹ is N; Z² is C(-L-R^10a); Z³ is N; each of R⁴ and R⁵ is hydrogen; R⁸ is selected from a group consisting of H and C_1-6 alkyl; -L-R^10a is selected from a group consisting of each of R¹³, R¹⁴, and R¹⁵ is H, or R¹³ is F, and each of R¹⁴ and R¹⁵ is H; X is substituted or unsubstituted piperazine, where the specified substituted piperazine is substituted with one group selected from a group consisting of CH₃ and CH₂CN; n is 0, and is a single bond or a double bond. The invention also relates to a drug for the treatment of cancer mediated by mutation of protein K-Ras G12C.

EFFECT: new compounds are obtained, which can be used in medicine for the treatment of cancer diseases.

51 cl, 3 tbl, 62 ex