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(19)

(11)

2 785 997

(13)

(51)

IPC

C07D239/72(2006-01-01)

A61K31/282(2006-01-01)

A61K31/517(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2019121686, 2017-12-18

(24)

Start date

2017-12-18

(22)

Actual filing date

2017-12-18

(45)

Published

2022-12-15

(72)

Inventor

Damstrup LarsGrombacher ThomasSirrenberg ChristianVassilev LyubomirZimmermann Astrid

(73)

Holder

Merck Patent Gmbh

COMBINATION OF PROTEIN KINASE INHIBITOR AND ADDITIONAL CHEMOTHERAPEUTIC AGENT Russian patent published in 2022 - IPC C07D239/72 A61K31/282 A61K31/517 A61P35/00

Abstract RU 2785997 C1

FIELD: medicine.

SUBSTANCE: invention relates to a method for the treatment of malignant neoplasm of the lung, expressing DNA-PK, in a patient who needs it, including administration to the specified patient of a compound 1: in a combination with etoposide and cisplatin, where the compound 1 is administered in amount from 10 to 800 mg, where etoposide is injected intravenously in amount of 100 mg/m², where cisplatin is injected intravenously in amount of 75 mg/m².

EFFECT: method for the treatment of malignant neoplasm of the lung, expressing DNA-PK, using a combination therapy, which shows synergism of a compound 1 in a combination with etoposide and cisplatin, is developed.

4 cl, 17 dwg, 7 tbl, 8 ex

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RU 2 785 997 C1

Authors

Damstrup Lars

Grombacher Thomas

Sirrenberg Christian

Vassilev Lyubomir

Zimmermann Astrid

Dates

2022-12-15—Published

2017-12-18—Filed