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(19)

(11)

2 757 373

(13)

(51)

IPC

A61K31/4995(2006-01-01)

A61K31/475(2006-01-01)

A61K31/337(2006-01-01)

A61K45/06(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2018102078, 2018-01-19

(24)

Start date

2011-11-11

(22)

Actual filing date

2018-01-19

(45)

Published

2021-10-14

(72)

Inventor

Moneo Ocana, VictoriaSantamaria Nunez, GemaGarcia Fernandez, Luis FranciscoGalmarini, Carlos MariaGuillen Navarro, Maria JoseAviles Marin, Pablo Manuel

(73)

Holder

Pharma Mar, S.A.

COMBINATION THERAPY WITH ANTITUMOR ALKALOID Russian patent published in 2021 - IPC A61K31/4995 A61K31/475 A61K31/337 A61K45/06 A61P35/00

Abstract RU 2757373 C2

FIELD: pharmaceutics.

SUBSTANCE: present invention relates to a pharmaceutical synergetic combination for the treatment of cancer containing therapeutically effective amount of PM01183 or its pharmaceutically acceptable salt and therapeutically effective amount of a mitosis inhibitor, where the mitosis inhibitor is selected from paclitaxel, docetaxel, vincristine and vinorelbine, while the cancer to be treated is selected from lung cancer, sarcoma, prostate cancer, stomach cancer, ovarian cancer, hepatoma, breast cancer, colorectal cancer, kidney cancer and brain cancer.

EFFECT: increase in or potentiation of therapeutic efficiency of anticancer drugs.

15 cl, 296 dwg, 26 tbl, 21 ex

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RU 2 757 373 C2

Authors

Moneo Ocana, Victoria

Santamaria Nunez, Gema

Garcia Fernandez, Luis Francisco

Galmarini, Carlos Maria

Guillen Navarro, Maria Jose

Aviles Marin, Pablo Manuel

Dates

2021-10-14—Published

2018-01-19—Filed