ANTIPROLIFERATIVE AGENTS FOR THE TREATMENT OF PAH Russian patent published in 2022 - IPC C07D471/04 C07D487/04 A61K31/4375 A61K31/519 A61P35/00 A61P9/12 

FIELD: organic chemistry.

SUBSTANCE: invention relates to organic chemistry, namely to a compound of formula I or a pharmaceutically acceptable salt thereof, where A represents CH or N; R¹ is C₁-C₂ alkyl; R² is C₁-C₄ alkyl; R³ is a 5-7 membered heterocyclyl containing 1 heteroatom selected from nitrogen or oxygen, C₃-C₈ cycloalkyl, where each of the 5-7 membered heterocyclyl is optionally substituted with 1 R⁵, where each of the C₃-C₈ cycloalkyl is optionally substituted with 1 R⁵ and further optionally substituted with 1 -N(R⁶)₂; R⁴ is a fragment having the structure

each R⁵ is independently selected from the group consisting of -F, -OH, C₁-C₄ alkyl, C₁-C₄ fluoroalkyl, C₁-C₄ alkoxy-C₁-C₄ alkyl-; each R⁶ is independently selected from the group consisting of H and C₁-C₂ alkyl; each R⁷ is independently H or C₁-C₂ alkyl; and each R⁸ is independently H. The invention also relates to specific compounds, the crystalline form of 3-acetyl-1-cyclopentyl-7-{[(3S,4R)-3-hydroxytetrahydro-2H-pyran-4-yl]amino}- 4-methyl-1,6-naphthyridin-2(1H)-one, a pharmaceutical composition based on a compound of formula I or said specific compounds, a method for treating a disease or disorder that would benefit from inhibition of CDK4 and/or CDK6 or abnormal cell growth, use compounds of formula I or specific specified compounds, the method for inhibition of CDK.

EFFECT: inhibition of CDK4 and/or CDK6 by a compound of formula I useful in the treatment of diseases such as pulmonary hypertension, pulmonary arterial hypertension, pulmonary hypertension with left heart disease, pulmonary hypertension with lung disease and/or hypoxemia, pulmonary hypertension due to chronic thrombotic and/or embolic disease; and a disease associated with pulmonary hypertension, including sarcoidosis, histiocytosis X, lymphangiomatosis, and pulmonary vascular compression or abnormal cell growth.

44 cl, 1 dwg, 17 tbl, 34 ex