FIELD: pharmaceutics.
SUBSTANCE: invention relates to compound of formula (IV) or its N-oxide, or pharmaceutically acceptable salt of such compounds, where A is O or CH2; Q is NH2, NHRb, NRbRc or OH, where each Rb and Rc independently represent C1-C6 alkyl; X is N or group CRx, where Rx is H; Y is H or Rd, where Rd is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl or C3-C8 cycloalkyl, and Rd is optionally substituted with one or more substitutes, selected from group consisting of halogen and C3-C8 cycloalkyl; each of R1 and R2 is H; each of Re, Rf, Rg and Rh independently represent group -M2-T2, where M2 is bond or O-C1-C4 alkyl linker, and T2 is H, halogen or RS4, where RS4 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl or oxetanyl, and each of O-C1-C4 alkyl linker and RS4 is optionally substituted with one or more substitutes, selected from group consisting of halogen, hydroxyl, cyano, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl and C1-C6 alkoxyl; and m equals to 0, 1 or 2. Invention relates to specific compounds. Disclosed compounds are intended for producing pharmaceutical composition with antiproliferative activity, including therapeutically effective amount of compound and pharmaceutically acceptable carrier. Besides compound is applied for treating leukemia and inhibiting DOT1L-mediated protein methylation.
EFFECT: substituted purine or 7-deazapurine compound effective in treating leukemia and inhibiting DOT1L-mediated protein methylation.
24 cl, 1 tbl, 3 dwg, 11 ex
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