FIELD: biotechnology.
SUBSTANCE: present invention relates to the field of biotechnology, in particular to interleukin-2 conjugates; it can be used in medicine. The invention discloses a conjugate of an option of IL-2 peptide with water-soluble polymer. Such a conjugate has increased time of action compared to unmodified natural peptide. In addition, amino acid substitutions in an option of IL-2 polypeptide are selected in such a way that to reduce activity in a receptor transmission of a signal to a beta-gamma IL-2 receptor.
EFFECT: invention can be used in medical practice as an immune-modulating therapeutic agent in the treatment of a number of autoimmune diseases.
21 cl, 5 dwg, 5 tbl, 4 ex
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