FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, in particular to interleukin-2 conjugates; it can be used in medicine. The invention discloses a conjugate of an option of IL-2 peptide with water-soluble polymer. Such a conjugate has increased time of action compared to unmodified natural peptide. In addition, a conjugating fragment included in a molecule of the claimed conjugate also weakens or blocks binding of IL-2 to IL-2Ra.
EFFECT: invention can be used in medical practice as an immune-modulating therapeutic agent in the treatment of a number of proliferative diseases.
28 cl, 6 ex, 11 tbl, 12 dwg
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