COMBINATION THERAPIES FOR TREATMENT OF HEPATOCELLULAR CARCINOMA Russian patent published in 2023 - IPC A61K31/47 A61K31/496 A61P35/00 

FIELD: medicine; oncology; therapy.

SUBSTANCE: group of inventions relates to the field of medicine, namely to oncology and therapy; it is intended for the treatment of hepatocellular carcinoma in a patient. A method for the treatment of hepatocellular carcinoma in a patient who needs it includes administration to the patient of a combination of N-(2-((6-(3-(2,6-dichlor-3,5-dimethoxyphenyl))-1-methylureido)pyrimidine-4-yl)amino)-5-(4-ethylpiperazine-1-yl)phenyl)acrylamide or its pharmaceutically acceptable salt and 4-[3-chlor-4-(N'-cyclopropylureido)phenoxy]-7-methoxyquinoline-6-carboxamide or its pharmaceutically acceptable salt. A pharmaceutical composition containing the specified compounds is also proposed. In other embodiments, the use of a combination of the specified compounds in the treatment of hepatocellular carcinoma and in the preparation of a drug for the treatment of hepatocellular carcinoma is provided.

EFFECT: use of the group of inventions allows for synergetic reduction in viability of hepatocellular carcinoma cells and inhibition of growth of hepatocellular carcinoma tumor in patients who need treatment.

21 cl, 2 dwg, 2 ex