FIELD: medicine.
SUBSTANCE: provided is a method for treating a tumor by means of combined therapy using lenvatinib and (6S,9aS)–N–benzyl–8–({6–[3–(4–ethylpiperazin–1–yl)azetidin–1–yl]pyridin–2–yl}methyl)–6–(2–fluoro–4–hydroxybenzyl)–4,7–dioxo–2–(prop–2–en–1–yl)hexahydro–2H–pyrazino[2,1–c][1,2,4]triazine-1(6H)-carboxamide.
EFFECT: improved procedure of treating a tumor.
12 cl, 22 dwg, 13 ex, 10 tbl
| Title |
Year |
Author |
Number |
| COMBINATION OF PD-1 ANTAGONIST, VEGFR/FGFR/RET TYROSINE KINASE INHIBITOR AND CBP/BETA-CATENIN INHIBITOR FOR TREATING CANCER |
2020 |
- Ozawa, Yoichi
- Funahashi, Yasuhiro
- Kato, Yu
|
RU2838452C1 |
| CRYSTAL (6S,9AS)-N-BENZYL-8-({6-[3-(4-ETHYLPIPERAZIN-1-YL)AZETIDIN-1-YL]PYRIDIN-2-YL}METHYL)-6-(2-FLUORINE-4-HYDROXYBENZYL)-4,7-DIOXO-2-(PROP-2-EN-1-YL)HEXAHYDRO-2H-PYRAZINO[2,1-C][1,2,4]TRIAZINE-1(6H)-CARBOXAMIDE |
2016 |
|
RU2723551C2 |
| ANTICANCER AGENT |
2016 |
- Odagami, Takenao
- Kouji, Hiroyuki
- Ozawa, Yoichi
- Hori, Yusaku
|
RU2729936C2 |
| (6S,9AS)-N-BENZYL-6-[(4-HYDROXYPHENYL)METHYL]-4,7-DIOXO-8-({6-[3-(PIPERAZIN-1-YL)AZETHYDIN-1-YL]PYRIDINE-2-YL}METHYL)-2-(PROP-2-EN-1-YL)-OCTAHYDRO-1H-PYRASINO[2,1-C][1,2,4]TRIAZINE-1-CARBOXAMIDE COMPOUND |
2014 |
- Inoue Satosi
- Yamamoto Yudzi
- Iso Kentaro
|
RU2669805C2 |
| ALPHA-SPIRAL MIMETICS AND METHODS ASSOCIATED WITH THEM |
2009 |
- Odagami Takenao
- Kogami Judzi
- Koudzi Khirojuki
|
RU2512538C2 |
| NEW COMPOUNDS MIMETICS AND USING THEM |
2008 |
- Chung Dzae Uk
- Dzung Khi-Kiung
- Dzung Kiung-Jun
- Dzeong Min-Vook
- La Khiun-Dzu
- Li Sang-Khak
- Kim Khoe-Moon
|
RU2457210C2 |
| NOVEL COMPOUNDS OF REVERSE TURN MIMETICS, METHOD OF THEIR MANUFACTURING AND APPLICATION |
2010 |
- Dzung Kiung-Jun
- Chung Dzae Uk
- Dzeong Min-Vook
- Dzung Khi-Kiung
- La Khiun-Dzu
- Ma Sang-Kho
- Li Jong-Sil
|
RU2515983C2 |
| ANELLATED 9-HYDROXY-1,8-DIOXO-1,3,4,8-TETRAHYDRO-2H-PYRIDO[1,2-A]PYRAZINE-7-CARBOXAMIDES - INTEGRASE INHIBITORS, METHODS FOR PREPARING AND USING THEREOF |
2019 |
- Ivashchenko Andrej Aleksandrovich
- Ivashchenko Aleksandr Vasilevich
- Mitkin Oleg Dmitrievich
- Savchuk Nikolaj Filippovich
|
RU2717101C1 |
| COMBINATION THERAPIES FOR TREATMENT OF HEPATOCELLULAR CARCINOMA |
2019 |
- Selveradzh, Anand Anand)
- Smit, Piter Peter)
|
RU2787993C2 |
| TRIARYL COMPOUNDS FOR TREATING PD-L1 DISEASES |
2020 |
- Fan, Pingchen
- Lange, Christopher
- Mali, Venkat Reddy
- Mcmurtrie, Darren, J.
- Malathong, Viengkham
- Punna, Sreenivas
- Singh, Rajinder
- Yang, Ju
- Zeng, Yibin
- Zhang, Penglie
|
RU2840345C2 |
