COMBINATION THERAPY FOR TREATMENT OF MAMMARY GLAND CANCER Russian patent published in 2022 - IPC A61K45/06 A61K31/519 A61K31/445 A61P35/00 

FIELD: medicine.

SUBSTANCE: invention relates to a method for the treatment of ERα-positive mammary gland cancer in a patient who needs it, including the injection to the patient of a combination of the effective amount of Erα inhibitor selected from a group consisting of (E)-N,N-dimethyl-4 -((2-((5-((Z)-4,4,4-trifluoro-1-(3-fluoro-1H-indazol-5-yl)-2-phenylbut-1-en-1-yl)pyridin-2-yl)oxy)ethyl)amino)but-2-enamide or its pharmaceutically acceptable salt, and the effective amount of CDK 4/6 inhibitor selected from a group consisting of 6-acetyl-8-cyclopentyl-5-methyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one (Palbociclib); N-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole-6-yl)pyrimidin-2-amine (abemacyclib); 7-cyclopentyl-2-(5-piperazin-1-ylpyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid idimethylamide (ribocyclib) or its pharmaceutically acceptable salt, as well as to the use of such a combination and a pharmaceutical composition containing such a combination for the treatment of Erα-positive mammary gland cancer.

EFFECT: obtaining a composition for the treatment of mammary gland cancer.

37 cl, 9 dwg, 4 ex