MONOVALENT ANTIBODIES TO PROPERDIN AND FRAGMENTS OF ANTIBODIES Russian patent published in 2023 - IPC C07K16/18 A61K39/395 A61P37/02 

FIELD: immunology; medicine.

SUBSTANCE: invention relates to immunology and medicine, in particular to an isolated monovalent antibody or its fragment, which specifically bind to human properdin, a bispecific antibody or its fragment, which specifically bind to human properdin and human serum albumin. Compositions for inhibition of an alternative path of a complement, containing such antibodies or their fragments, are also disclosed.

EFFECT: present invention allows for expansion of the arsenal of means for inhibition of properdin activity, which is an important therapeutic strategy for suppression of symptoms and delayed progression of diseases associated with a disorder of regulation of an alternative path of a complement.

10 cl, 20 dwg, 9 tbl, 5 ex