Show metadata Hide metadata

(19)

(11)

2 790 103

(13)

(51)

IPC

C07K16/18(2006-01-01)

A61K39/395(2006-01-01)

A61P37/02(2006-01-01)

(21) (22)

Application

2019124873, 2018-01-30

(24)

Start date

2018-01-30

(22)

Actual filing date

2018-01-30

(45)

Published

2023-02-14

(72)

Inventor

Sheridan, Douglas L.Tamburini, Paul P.Mack, Taneisha Ann-TanaraVoegtli, Walter C.

(73)

Holder

Alexion Pharmaceuticals, Inc.

MONOVALENT ANTIBODIES TO PROPERDIN AND FRAGMENTS OF ANTIBODIES Russian patent published in 2023 - IPC C07K16/18 A61K39/395 A61P37/02

Abstract RU 2790103 C2

FIELD: immunology; medicine.

SUBSTANCE: invention relates to immunology and medicine, in particular to an isolated monovalent antibody or its fragment, which specifically bind to human properdin, a bispecific antibody or its fragment, which specifically bind to human properdin and human serum albumin. Compositions for inhibition of an alternative path of a complement, containing such antibodies or their fragments, are also disclosed.

EFFECT: present invention allows for expansion of the arsenal of means for inhibition of properdin activity, which is an important therapeutic strategy for suppression of symptoms and delayed progression of diseases associated with a disorder of regulation of an alternative path of a complement.

10 cl, 20 dwg, 9 tbl, 5 ex

Similar patents RU2790103C2

Title	Year	Author	Number
PROCOAGULANT ANTIBODIES	2018	Torn, Karina Khansen, Byarne, Gram Jonsen, Laust, Bruun Kharndal, Mikkel, Nors Yan, Chzhizhu Estergaard, Khenrik Grajsen, Per, J Jokhansson, Eva Rash, Morten, Grenbek Chen, Dzyankhe Svensson, Anders Chzhu, Khajsun Chzhou, Zhun	RU2810094C2
BISPECIFIC ANTIBODY AND USE THEREOF	2021	Fang, Lijuan Zhang, Jing Hua, Shan Zhou, Pengfei	RU2839153C2
ANTIBODY TO TIGIT AND ITS USE	2019	Shi, Sinchzhen Chzhan, Pan Lyu, Tszyuntszyan	RU2786434C2
ANTIBODY TO CD3 AND ITS PHARMACEUTICAL USE	2019	Ying Hua Zhang Ling Yang Xiaoying Ge Hu Tao Weikang	RU2802272C2
PARVOVIRUS ANTIBODIES FOR USE IN VETERINARY SCIENCE	2020	Chzhan, Khantszyun Ngujen, Lam Retkliff, Ellen Chin, Richard Li, Shir Tszyann	RU2830441C2
ADVANCED PROCOAGULANT ANTIBODIES	2019	Torn, Karina Khansen, Byarne, Gram Jonsen, Laust, Bruun Kharndal, Mikkel, Nors Yan, Chzhizhu Estergaard, Khenrik Grejzen, Per, Dzh Jokhansson, Eva Rash, Morten, Grenbekh Chen, Tsziankhe Svensson, Anders Chzhu, Khajsun Chzhou, Zhun	RU2810748C2
BISPECIFIC ANTIBODIES	2020	Gandi, Prafull, S. Brejnkholt, Jens Estergaard, Khenrik	RU2818588C2
ANTIBODIES TO MESOTHELIN	2019	Munos-Olajya, Khose Fertin, Remi Vollerton, Frantsiska Tyuna, Mikhriban Bryuvis, Nil	RU2837574C2
ANTIBODIES AGAINST CXCR2 AND THEIR USE	2019	Chen, Doris, Shim Siew Poulton, Lynn, Dorothy Clarke, Adam Laine, David, Jose Simon Pollard, Matthew Cooksey, Bridget, Ann Doyle, Anthony Gill, Jason, William	RU2807067C2
BISPECIFIC ANTIBODY	2021	Shiku, Hiroshi Akahori, Yasushi Tanaka, Kento Yatsu, Ayaka Ichikawa, Junya Ohtsuka, Toshiaki Kozuma, Shiho Hashimoto, Ryuji Nakayama, Makiko Shinozaki, Naoya Nakamura, Kensuke Watanabe, Ichiro Furuzono, Shinji	RU2840407C1

RU 2 790 103 C2

Authors

Sheridan, Douglas L.

Tamburini, Paul P.

Mack, Taneisha Ann-Tanara

Voegtli, Walter C.

Dates

2023-02-14—Published

2018-01-30—Filed