FIELD: biochemistry.
SUBSTANCE: invention relates to a method for producing an antigen-binding molecule (ABM), which is a heterodimeric IgG antibody.
EFFECT: invention provides improved pairing of heavy and light chains of an antibody that maintains the correct pairing of HC and LC in an IgG bispecific antibody.
9 cl, 5 dwg, 3 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PRODUCING MULTISPECIFIC ANTIBODIES | 2018 |
|
RU2780629C1 |
| METHOD FOR THE PRODUCTION OF MULTI-SPECIFIC ANTIBODIES | 2018 |
|
RU2750721C2 |
| MODIFIED ANTIGEN-BINDING POLYPEPTIDE CONSTRUCTS AND USE THEREOF | 2015 |
|
RU2832921C1 |
| BISPECIFIC ANTIBODIES SPECIFIC TO PD1 AND TIM3 | 2016 |
|
RU2729371C1 |
| ANTIBODIES BINDING TO HLA-A2/WT1 | 2018 |
|
RU2815176C2 |
| TRI- OR TETRASPECIFIC ANTIBODIES | 2010 |
|
RU2570633C2 |
| ANTIBODIES BINDING TO GPRC5D | 2019 |
|
RU2797268C2 |
| BIVALENT BISPECIFIC ANTIBODIES | 2008 |
|
RU2547615C2 |
| CYTOTOXICITY-INDUCING THERAPEUTIC AGENT | 2011 |
|
RU2663123C2 |
| ANTIBODIES BINDING TO GPRC5D | 2020 |
|
RU2841523C2 |
