FIELD: biotechnology.
SUBSTANCE: invention relates to an antibody or its antigen-binding fragment that binds to GPRC5D, compositions containing it and a method for obtaining it, as well as to an isolated polynucleotide encoding it, a vector and a cell containing the above polynucleotide. Also a bispecific antigen-binding molecule that specifically binds to GPRC5D and CD3, a composition containing it and a method of obtaining it, as well as an isolated polynucleotide encoding it, a vector and a cell containing the above polynucleotide are disclosed.
EFFECT: invention is effective for the treatment of multiple myeloma.
37 cl, 15 dwg, 13 tbl, 12 ex
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