METHOD OF COMBINATION THERAPY OF B16 MELANOMA IN METRONOMIC MODE IN EXPERIMENT Russian patent published in 2023 - IPC A61K31/32 A61K33/243 A61P35/00 G09B23/28 

FIELD: medicine; experimental pharmacology.

SUBSTANCE: invention can be used for combined therapy of melanoma B16 in metronomic mode in the experiment. Female mice of the C57B1/6 line, 8 weeks old, weighing 21-22 g, are transplanted with the B16 melanoma strain. 48 hours after inoculation, bis(3,5-di-tert-butyl-4-hydroxyphenylthiolate) dimethyltin (Me3) is administered intraperitoneally once a day for 10 days at a single dose of 45 mg/kg in combination with cisplatin at a single dose of 1 mg/kg or (3,5-di-tert-butyl-4-hydroxyphenylthiolate) triphenyltin (Me5) in a single dose of 15 mg/kg in combination with cisplatin in a single dose of 1 mg/kg.

EFFECT: method provides effective antitumor and antimetastatic combined therapy of B16 melanoma in the metronomic mode in the experiment by administering a combination of Me3 with cisplatin or a combination of Me5 with cisplatin to C57B1/6 female mice.

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