COMPOSITION FOR USE IN THE TREATMENT OF EPILEPSY Russian patent published in 2023 - IPC A61K31/20 A61P25/08 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention can be used for the treatment of disorders associated with the AMPA receptor, in particular for the treatment of epilepsy. The use of a composition containing decanoic acid and octanoic acid in a ratio of 75:25 to 85:15 w/w is proposed for the treatment of epilepsy or the suppression of epileptic seizures, where decanoic acid and octanoic acid are presented in the form of triglycerides and where octanoic acid and decanoic acid make up at least 80 wt.% of the total content of fatty acids in the composition. Also, the use of a composition containing decanoic acid and octanoic acid in the form of triglycerides in a ratio of 75:25 to 85:15 w/w to reduce excitatory postsynaptic currents (EPSC) in a subject with epilepsy and to inhibit receptors α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) in a subject in need of such inhibition is proposed. Also, the use of octanoic acid to reduce or prevent the oxidation of decanoic acid in neurons, wherein decanoic and octanoic acids are present in the form of triglycerides in a composition containing decanoic and octanoic acids in a ratio of 75:25 to 85:15, is disclosed.

EFFECT: provides maximum inhibition of AMPA receptors and prevention of decanoic acid oxidation in neurons.

14 cl, 2 dwg, 1 tbl, 2 ex