NEW IMPROVED COMPOSITION CONTAINING AT LEAST ONE CADOTRIL Russian patent published in 2021 - IPC A61K31/223 A61K31/80 A61K47/10 A61K47/14 A61P1/00 A61P1/12 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to the field of pharmaceuticals and can be used for treatment of a subject suffering from a gastrointestinal disease or disorder. For this purpose, a semi-solid composition is proposed, containing at least one cadotril in an amount of 5% wt./ wt. to 50% wt./wt. and at least one excipient in form of a liquid lipid and/or propylene glycol in an amount from 20% wt./wt. to 90% wt./wt., wherein at least one cadotril crystallises forming small crystals and the excipient in form of a liquid lipid constitutes at least one medium chain triglyceride or at least an oil containing medium chain triglycerides or mixtures thereof. The semi-solid composition therein is in form of a tablet or capsule, is capable of supporting its own weight and retaining the shape, and is also capable to flow under pressure. The group of inventions also relates to a dosage unit containing said semi-solid composition, to an application of the composition for treatment of a subject suffering from a gastrointestinal disease or disorder, and to a method for treatment using the dosage unit.

EFFECT: group of inventions provides improved characteristics of absorption efficiency, bioavailability and/or controlled release such as extended or delayed release.

14 cl, 5 dwg, 6 tbl, 5 ex