ORAL RIFAMYCIN SV COMPOSITIONS Russian patent published in 2023 - IPC A61K31/4164 A61K9/20 A61K9/28 A61P1/10 A61P1/12 A61P31/04 

FIELD: chemistry.

SUBSTANCE: oral pharmaceutical compositions containing rifamycin SV or a pharmaceutically acceptable salt thereof, characterized in that they are formulated at a higher concentration (approximately 600 mg/tablet) and so as to obtain a modified proximal intestinal profile of rifamycin SV or a pharmaceutically acceptable salt thereof, that is, in the small intestine (duodenum, jejunum, and ileum). In one embodiment, the disclosed oral pharmaceutical compositions are used in the prevention and/or treatment of a subject's small bowel bacterial overgrowth syndrome (SIBO) and/or irritable bowel syndrome (IBS), and/or in the treatment of cholera. In one embodiment, the disclosed oral pharmaceutical compositions are used in the prevention and/or treatment of a subject's hepatic encephalopathy, cirrhosis, pouchitis, and/or spontaneous bacterial peritonitis.

EFFECT: in one embodiment, the disclosed oral pharmaceutical compositions are used in the prevention and/or treatment of a subject's non-alcoholic fatty liver disease, non-alcoholic fatty liver, or non-alcoholic steatohepatitis.

16 cl, 4 dwg, 14 tbl, 7 ex