KAPPA-OPIOID AGONISTS FOR TREATMENT OF DIARRHEA-PREVAILING IRRITABLE BOWEL SYNDROME AND ALTERNATE IRRITABLE BOWEL SYNDROME Russian patent published in 2012 - IPC A61K31/41 A61P1/00

Abstract RU 2441655 C2

FIELD: medicine.

SUBSTANCE: group of inventions is referred to medicine and is meant for treatment of diarrhea or diarrhea-prevailing irritable bowel syndrome (IBS-D) or IBS with alternate diarrhea and constipation (IBS-A). Peripherally selective kappa-opioid agonist is used, particularly N-methyl-N-[(1S)-1-phenyl-2-((3S))-3-hydroxypyrrolidine-1-yl) ethyl]-2,2- diphenylacetamide and/or its pharmaceutically acceptable salt. The dose is 0.3 mg - 2.0 mg/day.

EFFECT: reduction of IBS symptoms and stool frequency with diarrhea.

28 cl, 5 tbl, 2 ex, 14 dwg

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RU 2 441 655 C2

Authors

Mangel Allen

Dates

2012-02-10—Published

2008-03-07—Filed