METHODS FOR IMPROVING BLOCKADE THERAPY OF IMMUNE CHECKPOINTS THROUGH MICROBIOME MODULATION Russian patent published in 2023 - IPC A61K35/74 C12N1/21 

FILED: medicine.

SUBSTANCE: use of a composition for the treatment or prevention of skin cancer in a subject is disclosed, where the said composition contains at least one isolated or purified population of bacteria belonging to one or more of the Ruminococcaceae, Clostridiaceae, Lachnospiraceae, Micrococcaceae and/or Veilonellaceae families, where (a) the isolated or the purified bacterial population belongs to one or more species, subspecies or bacterial strains chosen from the group consisting of the species in Table 1 with an excess index (ei) above 0.5, or (b) the isolated or purified bacterial population is chosen from species in Table 2, indicated by the status of the response, responding to treatment (R). Also disclosed are the use of a composition containing an immune checkpoint inhibitor for treating or preventing skin cancer in a subject, a method for treating or preventing skin cancer, methods for predicting a response to an immune checkpoint inhibitor.

EFFECT: group of inventions provides microbiome modulation to improve the efficiency of blockade of immune checkpoints.

19 cl, 34 dwg, 10 tbl, 5 ex