FIELD: biotechnology; microbiology; genetic toxicology.
SUBSTANCE: invention relates to the field of biotechnology, and in particular to a method for assessing the potential mutagenicity of sulfonylureas and triazolpyrimidines using the Ames test on indicator strains of Salmonella typhimurium. It is also disclosed that this method allows the use of sulfonylurea and triazolpyrimidines in the maximum non-cytotoxic concentration due to the addition of isoleucine to the agar medium at a concentration of 1 to 5 mm.
EFFECT: invention is effective for determining the ability of these compounds to induce reverse gene mutations.
3 cl, 5 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| SALMONELLA TYPHIMURIUM BACTERIA STRAIN RESISTANT TO SULPHONYLUREAS AND TRIAZOLPYRIMIDINES FOR DETECTION OF POTENTIAL MUTAGENICITY OF CHEMICALS IN THE AIMS TEST | 2021 |
|
RU2777987C1 |
| STRAIN OF BACTERIA SALMONELLA TYPHIMURIUM B-14359, RESISTANT TO SULPHONYLUREAS AND TRIAZOLE PYRIMIDINES, FOR DETECTION OF POTENTIAL MUTAGENICITY OF CHEMICALS IN AMES TEST | 2023 |
|
RU2814258C1 |
| MICRIORGANISM MUTAGEN | 0 |
|
SU1616672A1 |
| MUTAGEN | 0 |
|
SU1723125A1 |
| METHOD FOR DETERMINING MUTAGENOUS ACTIVITY OF BOTTOM RESIDUES | 1990 |
|
SU1835924A1 |
| PROCESS FOR TREATING FOOD STUFFS | 1992 |
|
RU2041654C1 |
| COMPOSITION FOR TREATMENT OF PATIENTS WITH SQUAMOUS-HYPER- -KERATOTIC RUBROMYCOSIS FORM OF FOOT AND WRIST | 1998 |
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| STAPHYLOCOCCUS AUREUS A9 STRAIN CHARACTERIZED BY TOLERANCE TO CIPROFLOXACIN AND USED AS CONTROL TEST CULTURE TO DETERMINE SENSITIVITY TO ANTIBIOTICS | 2022 |
|
RU2809538C1 |
| SALMONELLA TUPHIMURIUM STRAIN USED FOR TESTING MUTAGENOUS AGENTS | 0 |
|
SU1261953A1 |
| USE OF SULFONATES FOR INHIBITING HUMAN LACTATE DEHYDROGENASE A | 2020 |
|
RU2751003C1 |
