COMPOUND WITH A CYCLIC STRUCTURE Russian patent published in 2023 - IPC C07D249/08 C07D401/14 C07D403/14 C07D405/14 A61K31/4196 A61K31/4439 A61K31/454 A61K31/5377 A61P1/00 A61P11/00 A61P17/00 A61P19/02 A61P21/02 A61P25/00 A61P27/02 A61P29/00 

FIELD: pharmaceutical chemistry.

SUBSTANCE: group of inventions relates to a compound of formula (1') and specific compounds indicated in the claims, their pharmacologically acceptable salts, a pharmaceutical composition, an application and a method for preventing and treating an inflammatory disease based on them. In the formula (1'), R¹ represents a hydrogen atom, a carboxy group, a cyano group, a fluorine atom, a chlorine atom, a methyl group, an isopropyl group, a tert-butyl group, a trifluoromethyl group, a trifluoromethoxy group, a cyclopropylmethoxy group, 1,1-difluoro-2-methylpropyl group, 1,1-difluoro-2,2-dimethylpropyl group, 1-methyl-1-cyclobutyl group, methoxycarbonyl group, ethoxycarbonyl group, isopropoxycarbonyl group, 1-hydroxy-1-methylethyl group, azetidine-1-carbonyl group, 3-methyloxetan-3-yl group, 4,5-dihydrooxazol-2-yl group or cyclopropylcarbonyl group; R^6d represents a hydrogen atom or a methyl group; A¹ is ═N- or ═CH-; X is benzene, pyridine or cyclohexane, each containing 2 bonds; J is a ring selected from those given in the claims; Y and its substituents are presented in the claims.

EFFECT: 1,2,4-triazole derivatives that increase the content of IL-10 which can be used to prevent and treat inflammatory diseases.

22 cl, 7 dwg, 33 tbl, 40 ex