HYBRID DERIVATIVES OF (1H-1,2,4) TRIAZOLE AND SULPHUR-CONTAINING HETEROCYCLES: DERIVATIVES OF THIAZOLIDINE-2,4-DIONE, THIOMORPHOLINE-3-ONE, AND 1,4-THIAZEPAN-3-ONE, EXHIBITING ANTIMICROBIAL ACTIVITY Russian patent published in 2022 - IPC C07D417/06 C07D417/14 A61K31/381 A61K31/4196 A61P31/10 

FIELD: pharmaceuticals.

SUBSTANCE: group of inventions relates to pharmaceutical chemistry and includes a compound by the general formula (I) or a stereoisomer, enantiomer, diastereoisomer, racemate, pharmaceutically acceptable salt thereof. In the formula (I), R₁ constitutes hydrogen or methyl; Q constitutes a covalent bond, -NH-, -NR₅-, -(CH₂)_n-NH-, -(CH₂)_n-NR₅- or -(CH₂)_n-, wherein n=0, 1 or 2; R₅ constitutes a -C_1-4-alkyl, benzyl or benzoyl, wherein the benzyl or benzoyl may optionally be substituted with 0 to 2 substituents, independently selected from a partially or fully halogenated -C_1-4-alkyl, halogen; X constitutes -CH- or -N-; A is the fragment specified in the claim, R₃ and R₄ are independently selected from fluorine or chlorine. The group of inventions also relates to a pharmaceutical composition containing a compound by the formula (I) and to an application thereof.

EFFECT: compound by the general formula (I), applied as an antifungal agent for treating and/or preventiing an infectious disease of a microbial etiology in a subject, caused by a fungal infection, in particular, dermatophytosis, superficial mycosis, candidiasis of the skin and/or nails, vaginal candidiasis, candidiasis of internal organs, oral candidiasis, or endocarditis.

14 cl, 5 dwg, 1 tbl