THERAPEUTIC AND DIAGNOSTIC METHODS FOR MAST CELL-MEDIATED INFLAMMATORY DISEASES Russian patent published in 2023 - IPC A61K39/395 A61K45/06 C07K16/40 C07K16/42 C12Q1/6883 G01N33/573 A61P11/06 

FIELD: biotechnology.

SUBSTANCE: following are presented: a method for treating patients with a mast cell-mediated inflammatory disease, methods for determining whether patients with a mast cell-mediated inflammatory disease may respond to therapy, for example, therapy comprising an agent selected from the group consisting of a tryptase antagonist, an Fc-epsilon receptor (FcεR), an IgE+ depleting B cell antibody, a mast cell or basophil depleting antibody, a protease-activated receptor 2 (PAR2) antagonist, an IgE antagonist, and combinations thereof, methods of selecting therapy for a patient with a mast cell-mediated inflammatory disease. Also the following are indicated: a method for monitoring the response of a patient with an inflammatory disease mediated by mast cells, a kit for identifying a patient with an inflammatory disease mediated by mast cells, the use of a tryptase antagonist for the manufacture of a drug for the treatment of a patient with an inflammatory disease, and methods for treating a patient with asthma.

EFFECT: invention makes it possible to create new effective therapeutic and diagnostic methods for the treatment of inflammatory diseases mediated by mast cells.

143 cl, 1 tbl, 4 dwg, 5 ex