ROUTES OF APPLICATION OF PHOSPHODIESTERASE INHIBITORS Russian patent published in 2023 - IPC A61K31/4375 A61K31/438 A61K31/4545 A61K31/496 A61K31/55 A61P9/04 C07D471/04 

FIELD: medicine.

SUBSTANCE: following is proposed: the use of a phosphodiesterase 9 (PDE9) inhibitor compound represented by the general formula (I) and its pharmaceutically acceptable salts, tautomers and deuterated compounds in the manufacture of a medicament for the treatment of diseases associated with heart failure in mammals, where each of X₁ and X₄ is CH; X₂ is N and X₃ is CR₃; R₃ at each occurrence is independently selected from hydrogen, C_1-6 alkyl, C_1-6 alkylcarbonyl, where C_1-6 alkyl is unsubstituted or substituted with one or more hydroxyls; L is a bond; ring A represents; each R₁ is independently selected from hydrogen, deuterium, C_1-6 alkyl, C_1-6 alkoxy; m is 1, 2 or 3; and R₂ is hydrogen. Also the following is disclosed: the use of specific compounds in the manufacture of a medicament for the treatment of diseases associated with heart failure in mammals, and a kit containing a compound represented by the general formula (I) and instructions for using the compound in the treatment of diseases associated with heart failure in mammals.

EFFECT: providing a new application of the PDE9 inhibitor in the treatment of heart failure.

10 cl, 8 dwg, 9 tbl, 25 ex