FIELD: chemistry.
SUBSTANCE: present invention refers to a compound of formula (I), or its pharmaceutically acceptable salt and stereoisomer, where R1, R2, X, Y, P, W and Ar are as defined in the claim. Compound of formula (I) of the present invention can be used in preparing a drug for treating cancer diseases mediated by abnormalities of multikinases. Also disclosed is a crystalline form I of compound of 4-(5-(2-chlorophenyl)-3-methyl-2,10-dihydropyrazolo[4,3-b]pyrido[4,3-e]-[1,4]diazepin-8-yl)morpholine, having formula (III), X-ray diffraction pattern of which on powder of crystalline form I has characteristic peaks at 7.4 ± 0.2°; 17.9 ± 0.2°; 18.9 ± 0.2°; 19.4 ± 0.2°; 21.5 ± 0.2° and 23.7 ± 0.2°, and a method for production thereof. Invention also relates to a method of producing a compound of formula (III) and intermediate compounds for its preparation, pharmaceutical compositions containing a compound of formula (I) or a crystalline form of the compound of formula (III), and a method of treating cancer diseases mediated by abnormalities of multikinases.
; 
EFFECT: inhibitor multikinase and its crystalline form and application are disclosed.
18 cl, 2 dwg, 9 tbl, 17 ex
| Title | Year | Author | Number |
|---|---|---|---|
| NEW INHIBITOR BASED ON A QUINOLINE DERIVATIVE | 2019 |
|
RU2802283C2 |
| INHIBITORS, A METHOD OF THEIR PREPARATION AND USE | 2019 |
|
RU2806033C2 |
| TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DESTROYERS | 2017 |
|
RU2797244C2 |
| THIENOPYRROL DERIVATIVES FOR APPLICATION FOR TARGETING PROTEINS, COMPOSITIONS WITH SAID DERIVATIVES, METHODS AND APPLICATIONS | 2017 |
|
RU2771166C2 |
| PYRIMIDINE DERIVATIVES AS INHIBITORS OF PD1/PD-L1 ACTIVATION | 2018 |
|
RU2783211C2 |
| ESTROGEN RECEPTOR PROTEOLYSIS MODULATORS AND RELATED USES THEREOF | 2018 |
|
RU2797808C2 |
| BICYCLIC HETEROCYCLIC COMPOUNDS AND THEIR APPLICATIONS | 2020 |
|
RU2811612C2 |
| NITROGEN-CONTAINING HETEROCYCLIC AROMATIC COMPOUND, METHOD FOR PRODUCTION THEREOF, PHARMACEUTICAL COMPOSITION BASED THEREON AND USE THEREOF | 2017 |
|
RU2729999C1 |
| SERINE-THREONINE PROTEIN KINASE AND PARP MODULATORS | 2013 |
|
RU2681209C2 |
| POLYCYCLIC AGENTS FOR TREATING RESPIRATORY SYNCYTIAL VIRAL INFECTIONS | 2007 |
|
RU2486185C2 |
