FIELD: medicine, pharmaceutics.
SUBSTANCE: there are described new compounds of general formula (I):
in the form of a separate stereoisomer or mixed stereoisomers or in the form of its pharmaceutically acceptable salt wherein R1 is indazolyl or substituted indazolyl; R6 is C6aryl or C6-12aryl substituted by halogen, hydroxy, cyano and C1-6alkoxy; or C6heterocyclyl containing 1-2 heteroatoms specified in nitrogen or oxygen; each X2 and X3 independently mean hydrogen, hydroxy or phosphate.
EFFECT: prepared compounds may be used for preparing a drug preparation for treating or preventing cancer, particularly acute myeloid leukemia.
6 cl, 6 tbl, 8 ex, 4 dwg
Title | Year | Author | Number |
---|---|---|---|
NOVEL COMPOUNDS, REPRESENTING REVERSE-TURN MIMETICS, AND THEIR APPLICATION | 2008 |
|
RU2470024C2 |
MIMETICS WITH REVERSE CONFIGURATIONS AND METHODS OF THEIR ADMINISTRATION | 2004 |
|
RU2342387C2 |
MODULATION OF BETA-CATENIN/TCF-ACTIVATED TRANSCRIPTION | 2004 |
|
RU2383547C2 |
THIA(DIA)ZOLES AS QUICK-DISSOCIATING ANTAGONISTS OF DOPAMINE 2 RECEPTOR | 2008 |
|
RU2489431C2 |
IMIDAZOPYRIDINE COMPOUNDS AS PAD INHIBITORS | 2018 |
|
RU2782743C2 |
DERIVATIVES OF SUBSTITUTED TRIAZOLDIAMINE, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD FOR ITS PREPARING | 2001 |
|
RU2274639C2 |
1,5,6-SUBSTITUTED 2-OXO-3-CYANO-1,6A-DIAZATETRAHYDROFLUORANTHENES | 2006 |
|
RU2389730C2 |
PEPTIDILE HETEROCYCLES USED TO TREAT THROMBIN- ASSOCIATED DISEASES | 1996 |
|
RU2181125C2 |
NEW COMPOUNDS AS MODULATOR OF OPIOTIC RECEPTORS | 2003 |
|
RU2332411C2 |
AROMATIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEREOF | 1996 |
|
RU2198878C2 |
Authors
Dates
2012-07-27—Published
2008-10-15—Filed