FIELD: medicine; pharmaceuticals.
SUBSTANCE: invention relates to a method for improving the pathological condition of the bone in a patient with acid sphingomyelinase deficiency (ASMD), and the method includes administering multiple doses of olipudase-alpha to the patient, where improvement in the abnormal condition of the bone is indicated by an improvement in the bone condition of the patient after multiple doses of olipudase-alpha.
EFFECT: technical result is alleviating the pathological conditions of the bone by enzyme replacement therapy using ASM in patients with ASMD, including an increase in their bone density and a decrease in their bone marrow "load".
23 cl, 4 dwg, 3 tbl, 1 ex
Title |
Year |
Author |
Number |
USE OF ANTIBODIES TO SCLEROSTIN FOR TREATING OSTEOGENESIS IMPERFECTA |
2017 |
- Yunker, Uve
- Knejssel, Mikhaela
- Kholl, Entoni Kent
- Eudi, Rena Dzhoj
- Riggs, Mettyu Menning
|
RU2789033C2 |
PHARMACEUTICAL COMPOSITION FOR USE IN PREVENTING AND/OR TREATING A DISEASE THAT DEVELOPS OR PROGRESSES AS A RESULT OF REDUCING OR LOSING ACTIVITY OF THE BLOOD COAGULATION FACTOR VIII AND/OR ACTIVATED COAGULATION FACTOR VIII |
2015 |
|
RU2721910C2 |
POLYPEPTIDES THAT ARE SOLUBLE RECEPTORS OF FIBROBLAST GROWTH FACTOR 3 (sFGFR3), AND WAYS OF THEIR APPLICATION |
2017 |
- Guz, Elvire
- Garsiya, Stefani
|
RU2751483C2 |
METHODS OF TREATING TISSUE CALCIFICATION |
2015 |
- O Neill W. Charles
- Cheng Zhiliang
- Grabowski Gregory
- Askew Kim Lynette
- Khan Tayeba
- Hsia Nelson
- Quinn Anthony
|
RU2770698C2 |
PHARMACEUTICAL COMPOSITION AND METHOD OF PREVENTION AND TREATMENT OF LYSOSOMAL ENZYME DEFICIENCY IN SUBJECT WITH TYPE II MUCOPOLYSACCHARIDOSIS |
2023 |
- Shukurov Rakhim Rakhmankulyevich
- Reshetnik Elizaveta Vyacheslavovna
- Khamitov Ravil Avgatovich
- Shuster Aleksandr Mikhajlovich
|
RU2814280C1 |
COMBINED COMPOSITION CONTAINING FGF-18 COMPOUND |
2016 |
- Ladel, Christoph, H.
- Guehring, Hans
- Gigout, Anne
- Brenneis, Christian
|
RU2745453C2 |
COMPOSITIONS FOR THE TREATMENT OF PATHOLOGICAL CONDITIONS OF CALCIFICATION AND THEIR APPLICATION METHODS |
2016 |
- Braddock Demetrios
- Albright Ronald
|
RU2757417C2 |
TREATMENT OF MUSCULAR WEAKNESS WITH ALKALINE PHOSPHATASES |
2017 |
|
RU2754558C2 |
METHOD FOR PREVENTION AND TREATMENT OF CANCER METASTASES AND BONE LOSS CAUSED BY CANCER METASTASES |
2007 |
|
RU2470665C2 |
TREATMENT APPROACH DESIGNED TO TREAT WITH A COMBINATION OF ANTI-CD19 ANTIBODY AND VENETOCLAX |
2018 |
- Kelemen Peter
- Schwarz Michael
- Winderlich Mark
- Heeger Steffen
- Weinelt Dominika
|
RU2802812C2 |