FIELD: pharmaceutical industry.
SUBSTANCE: method for increasing the potency of relaxin. The composition for increasing relaxin potency contains an mRNA polynucleotide compounded in an ionizable lipid nanoparticle, where the mRNA polynucleotide contains an open reading frame encoding a relaxin-based fusion protein containing the amino acid sequence set in SEQ ID NO: 1, and an immunoglobulin (Ig) fragment, wherein the ionizable lipid nanoparticle contains an ionizable lipid, which is compound 18, having the structure.
EFFECT: increasing the relaxin potency in the subject.
9 cl, 5 tbl, 15 ex, 11 dwg
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