POLYNUCLEOTIDES ENCODING RELAXIN Russian patent published in 2023 - IPC A61K9/51 A61K31/7105 A61K38/17 A61K47/14 A61P9/00 C07K14/64 C07K16/26 C12N15/52 C12N15/62 

Abstract RU 2795683 C2

FIELD: pharmaceutical industry.

SUBSTANCE: method for increasing the potency of relaxin. The composition for increasing relaxin potency contains an mRNA polynucleotide compounded in an ionizable lipid nanoparticle, where the mRNA polynucleotide contains an open reading frame encoding a relaxin-based fusion protein containing the amino acid sequence set in SEQ ID NO: 1, and an immunoglobulin (Ig) fragment, wherein the ionizable lipid nanoparticle contains an ionizable lipid, which is compound 18, having the structure.

EFFECT: increasing the relaxin potency in the subject.

9 cl, 5 tbl, 15 ex, 11 dwg

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RU 2 795 683 C2

Authors

Sya Chzhinan

Tikho Barri

Briankon-Eris Nadezhe

Dosis Atlanasios

De Pichchotto Sejmur

Presnyak Vladimir

Khodzh Stiven

Makfaden Ien

Benenato Kerri

Kumarasinkhe Ellalakhevadzh Satiadzhit

Dates

2023-05-05Published

2017-05-18Filed