FIELD: biotechnology.
SUBSTANCE: bispecific agonistic CD28 antigen-binding molecule is proposed that targets CD28 and CD19 and is characterized by univalent binding to CD28. Also the following are provided: a polynucleotide and an expression vector encoding the said molecule, and a host cell containing them. The invention also relates to a method of obtaining bispecific molecules and methods of their use.
EFFECT: invention can be used in cancer therapy.
20 cl, 157 dwg, 46 tbl, 22 ex
| Title | Year | Author | Number |
|---|---|---|---|
| TRISPECIFIC BINDING PROTEINS, RELATED METHODS AND VERSIONS OF USE THEREOF | 2020 |
|
RU2822200C2 |
| IMPROVED ANTIGEN-BINDING RECEPTORS | 2018 |
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| CD40 LIGAND THERAPEUTIC ANTIBODIES | 2018 |
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| TRISPECIFIC AND/OR TRIVALENT BINDING PROTEINS USING CROSSOVER FORMAT WITH DOUBLE VARIABLE DOMAIN (CODV) FOR TREATING INFECTION CAUSED BY HIV | 2020 |
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| ISOLATED ALTERNATIVE INTRACELLULAR SIGNALLING DOMAIN OF CHIMERIC ANTIGEN RECEPTOR AND CHIMERIC ANTIGEN RECEPTOR INCLUDING IT | 2019 |
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| ANTIBODIES TO CD38 AND COMBINATIONS WITH ANTIBODIES TO CD3 AND CD28 | 2018 |
|
RU2812910C2 |
| CANINIZED ANTI-HUMAN CTLA-4 ANTIBODIES | 2020 |
|
RU2822460C2 |
| ANTI-CANINE CTLA-4 ANTIBODY | 2020 |
|
RU2818586C2 |
| TRISPECIFIC BINDING PROTEINS BINDING CD38, CD28 AND CD3, AS WELL AS METHODS OF USE FOR TREATING VIRAL INFECTION | 2019 |
|
RU2820351C2 |
| CHIMERIC ANTIGEN RECEPTORS TARGETED TO FC RECEPTOR-LIKE PROTEIN 5, AND THEIR USE | 2015 |
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RU2779747C2 |
