BISPECIFIC ANTIGEN-BINDING MOLECULES CONTAINING ANTI-FAP CLONE 212 Russian patent published in 2023 - IPC C07K16/28 C07K16/40 C07K16/46 A61P35/00 

FIELD: biotechnology.

SUBSTANCE: following is described: a group of inventions including a bispecific binding molecule capable of specifically binding to a member of the tumor necrosis factor receptor (TNFR) CD40 family and to fibroblast activation protein (FAP), an antibody that specifically binds to FAP, an isolated nucleic acid encoding a bispecific antibody, an isolated nucleic acid encoding an antibody that specifically binds to FAP, an expression vector that allows the expression of a bispecific antigen-binding molecule, a host cell to obtain a bispecific antigen-binding molecule, a method of producing a bispecific antigen-binding molecule, a pharmaceutical composition for the treatment of diseases associated with FAP and CD40, the use of a bispecific antigen-binding molecule or pharmaceutical composition in the treatment of cancer associated with FAP and CD40, the use of a bispecific antigen-binding molecule in the treatment of cancer associated with FAP and CD40 (options).

EFFECT: invention expands the arsenal of agents that specifically bind to CD40 and FAP.

34 cl, 18 dwg, 35 tbl, 6 ex