PAIR-BORPHENYLALANINE DERIVATIVE AND A COMPOSITION CONTAINING THESE, AND A KIT FOR OBTAINING THE MENTIONED DERIVATIVE AND COMPOSITION Russian patent published in 2023 - IPC C08F8/42 C08F16/06 C08G69/48 A61K31/69 A61K41/00 A61K47/58 A61K49/00 A61P35/00 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a para-borophenylalanine derivative comprising a polymer linked, either directly or via a linker, to a group represented by formula (I). In formula (I): the arrows indicate the bond to the adjacent atom, X¹-X⁴ are each independently H, ¹⁸F or ¹⁹F. The polymer is selected from the group consisting of polyvinyl alcohol, polyether and polypeptide, and the number average molecular weight of the para-borophenylalanine derivative is 1,000 Da or more. Also pharmaceutical compositions containing a para-borophenylalanine derivative and a kit for preparing pharmaceutical compositions are proposed.

EFFECT: invention makes it possible to implement selective accumulation and long-term retention of boron in tumors, while achieving an excellent ratio of boron concentrations in tumor/normal tissues and a ratio of boron concentrations in tumor/blood.

12 cl, 34 dwg, 1 tbl, 24 ex