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2 799 446

(13)

(51)

IPC

C07D285/13(2006-01-01)

C07D417/12(2006-01-01)

A61K31/433(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2021101041, 2019-06-21

(24)

Start date

2019-06-21

(22)

Actual filing date

2019-06-21

(45)

Published

2023-07-05

(72)

Inventor

Farni, ElliotShiroodi, Rookhollakh, KazemSyun, ChzhaominChzhan, TsinvejO`Konnor, MettyuKhalvorsen, DzheffChzhao, KhunyujBaumgartner, KristinaFrost, Dzhennifer, M.Kim, FilEbbot, Dzhejson, R.Bogdan, EndryuIkonomu, KristosVan, Syuetsin

(73)

Holder

Kaliko Lajf Sajensiz ElelsiEbbvi Ink.

PROTEIN-TYROSINPHOSPHATASE INHIBITORS AND METHODS OF THEIR USE Russian patent published in 2023 - IPC C07D285/13 C07D417/12 A61K31/433 A61P35/00

Abstract RU 2799446 C2

FIELD: pharmaceuticals.

SUBSTANCE: herein the compounds, compositions, and methods useful for inhibiting a protein tyrosine phosphatase, such as a non-receptor type 2 protein tyrosine phosphatase (PTPN2) and/or a non-receptor type 2 protein tyrosine phosphatase are provided. The invention relates to a compound which is

and its pharmaceutically acceptable salt.

EFFECT: new compound has been obtained that is suitable for inhibiting protein tyrosine phosphatase, for example, non-receptor type 2 protein tyrosine phosphatase (PTPN2) and/or non-receptor type 1 protein tyrosine phosphatase (PTPN1), and for the treatment of associated diseases, disorders and conditions that respond favorably to for treatment with PTPN1 or PTPN2 inhibitors, such as cancer or metabolic disorders.

4 cl, 227 ex, 6 tbl

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RU 2 799 446 C2

Authors

Farni, Elliot

Shiroodi, Rookhollakh, Kazem

Syun, Chzhaomin

Chzhan, Tsinvej

O`Konnor, Mettyu

Khalvorsen, Dzheff

Chzhao, Khunyuj

Baumgartner, Kristina

Frost, Dzhennifer, M.

Kim, Fil

Ebbot, Dzhejson, R.

Bogdan, Endryu

Ikonomu, Kristos

Van, Syuetsin

Dates

2023-07-05—Published

2019-06-21—Filed