FIELD: chemistry.
SUBSTANCE: invention relates to use of compounds of general formula
, where m equals 0, 1, 2 or 3; each R1 independently denotes halogen, cyano, hydroxyl, C3-C6cycloalkyl, C1-C6alkoxy, C1-C6halogenalkyl, C1-C6halogenalkoxy, -NR9R10, C1-C6alkylthio, C1-C6alkylcarbonyl, phenyl or C1-C6alkyl; Z denotes a bond or a (CH2)q group, where q equals 1 or 2; Z2 denotes a bond or a CH2 group, provided that both Z1 and Z2 do not denote a bond at the same time; Q denotes an oxygen or sulphur atom or a CH2 or a NH group; R2 denotes a group 
, n equals 0; each R4, R5, R6 and R7 independently denotes a hydrogen atom or a C1-C6alkyl group, or R4, R5, R6 and R7 together denote a C1-C4alkylene chain which binds two carbon atoms to which they are bonded to form a 4-7-member saturated carbocycle, or each R5, R6 and R7 denotes a hydrogen atom, and R4 and R8 together with carbon atom to which they are bonded form a 5-6-member saturated carbocycle; R8 denotes a hydrogen atom, a C1-C6alkyl group, or is bonded to R4 as defined above; each R9 and R10 independently denotes a hydrogen atom; R15 denotes -OC(O)NR17R18 or -NHC(O)R20; t equals 0, 1, 2 or 3; each R16 independently denotes a halogen, cyano, hydroxyl, C3-C6cycloalkyl, C1-C6alkoxy, C1-C6halogenalkyl, C1-C6halogenalkoxy, -NR21R22, C1-C6alkylthio, C1-C6alkylcarbonyl, phenyl or C1-C6alkyl; each R17 and R18 independently denotes a hydrogen atom or C1-C6alkyl group; R20 denotes C1-C6alkyl, C3-C6cycloalkyl, C5-C6cycloalkenyl, phenyl or a 5-6-member nitrogen-containing heterocyclic ring system which may be substituted with C1-C6alkyl; each R21 and R22 independently denotes a hydrogen atom; or to pharmaceutically acceptable salts or solvates thereof in preparing a medicinal agent for use in treating inflammatory diseases. The invention also relates to use of compounds of formula (I) in preparing a medicinal agent for use in treating respiratory tract diseases.
EFFECT: use of biologically active compounds, capable of modulating CCR1 receptor activity.
24 cl, 63 ex
