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(19)

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2 288 228

(13)

(51)

IPC

C07D403/12(2006-01-01)

C07D403/14(2006-01-01)

C07D401/12(2006-01-01)

C07D233/78(2006-01-01)

A61K31/4166(2006-01-01)

A61K31/4439(2006-01-01)

A61K31/454(2006-01-01)

(21) (22)

Application

2003127734/04, 2002-03-13

(24)

Start date

2002-03-13

(22)

Actual filing date

2002-03-13

(45)

Published

2006-11-27

(72)

Inventor

Ehriksson AndersLepiste MattiLundkvist Mikaehl'Munk Af Rozenskel'D MagnusZlatojdskij Pavol

(73)

Holder

Astrazeneka Ab

INHIBITORS OF METALLOPROTEINASES, THEIR USING AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 2006 - IPC C07D403/12 C07D403/14 C07D401/12 C07D233/78 A61K31/4166 A61K31/4439 A61K31/454

Abstract RU 2288228 C2

FIELD: organic chemistry, biochemistry, medicine, pharmacy.

SUBSTANCE: invention describes compounds of the general formula (I): wherein X means -NR1; Y₁ and Y₂ represent oxygen atom (O); Z is chosen from -SO, -SO₂; m = 1; A represents a direct bond; R1 means hydrogen atom (H); R2 and R3 are chosen independently from H, (C₁-C₆)-alkyl, heterocycloalkyl, phenyl, heteroaryl, phenylalkyl, phenylheteroalkyl, heteroarylalkyl, heterocycloalkylalkyl; R4 represents H; R5 represents monocyclic, bicyclic or tricyclic group. Also, invention describes a pharmaceutical composition and using compounds in preparing a medicinal agent for using in treatment of diseases or states mediated by one ore more enzymes representing metalloproteinase. Compounds of the formula (I) are useful as inhibitors of metalloproteinases being especially as inhibitors of MMP12.

EFFECT: valuable medicinal and biochemical properties of compounds and pharmaceutical composition.

14 cl, 16 ex

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RU 2 288 228 C2

Authors

Ehriksson Anders

Lepiste Matti

Lundkvist Mikaehl'

Munk Af Rozenskel'D Magnus

Zlatojdskij Pavol

Dates

2006-11-27—Published

2002-03-13—Filed