FIELD: organic chemistry, biochemistry, medicine, pharmacy.
SUBSTANCE: invention describes compounds of the general formula (I): wherein X means -NR1; Y1 and Y2 represent oxygen atom (O); Z is chosen from -SO, -SO2; m = 1; A represents a direct bond; R1 means hydrogen atom (H); R2 and R3 are chosen independently from H, (C1-C6)-alkyl, heterocycloalkyl, phenyl, heteroaryl, phenylalkyl, phenylheteroalkyl, heteroarylalkyl, heterocycloalkylalkyl; R4 represents H; R5 represents monocyclic, bicyclic or tricyclic group. Also, invention describes a pharmaceutical composition and using compounds in preparing a medicinal agent for using in treatment of diseases or states mediated by one ore more enzymes representing metalloproteinase. Compounds of the formula (I) are useful as inhibitors of metalloproteinases being especially as inhibitors of MMP12.
EFFECT: valuable medicinal and biochemical properties of compounds and pharmaceutical composition.
14 cl, 16 ex
Title | Year | Author | Number |
---|---|---|---|
DERIVATIVES OF IMIDAZOLIDINE-2,4-DIONE, PHARMACEUTICAL COMPOSITIONS COMPRISING THEREOF AND THEIR USING | 2002 |
|
RU2285695C2 |
INHIBITORS OF METALLOPROTEINASES, THEIR USING AND PHARMACEUTICAL COMPOSITIONS BASED ON THEREOF | 2002 |
|
RU2293730C2 |
INHIBITORS OF METALLOPROTEINASES, THEIR USING AND PHARMACEUTICAL COMPOSITIONS BASED ON THEREOF | 2002 |
|
RU2293729C2 |
NEW HYDANTOIC DERIVATIVES FOR TREATING OBSTRUCTIVE AIRWAY DISEASES | 2005 |
|
RU2386629C2 |
PIPERIDINE- AND PIPERAZINE-SUBSTITUTED N-HYDROXYFORMAMIDES AS INHIBITORS OF METALLOPROTEINASES | 2001 |
|
RU2283306C2 |
DERIVATIVES OF PIPERIDINE, METHODS FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF | 2001 |
|
RU2298550C2 |
DERIVATIVES OF NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS, METHODS FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHODS FOR TREATMENT OF INFLAMMATORY DISEASES AND RESPIRATORY WAYS DISEASES | 2001 |
|
RU2265011C2 |
NOVEL COMPOUNDS | 2001 |
|
RU2419608C2 |
PROTEIN TYROSINE KINASE ACTIVITY INHIBITORS | 2009 |
|
RU2533827C2 |
DERIVATIVES OF 3-SUBSTITUTED 4-ARYLQUINOLIN-2-ONE AS MODULATORS OF POTASSIUM CHANNEL | 1999 |
|
RU2240998C2 |
Authors
Dates
2006-11-27—Published
2002-03-13—Filed