FIELD: medicine.
SUBSTANCE: invention relates to antibody-drug conjugates wherein the antibodies specifically bind to the transferrin receptor TFR and the drugs are preferably selected from cytotoxic agents. The invention relates to antibody-drug conjugates, where the antibodies specifically bind to the transferrin receptor TFR and the drug is monomethylauristatin E.
EFFECT: such antibody-drug conjugates can be used in particular in the treatment of proliferative diseases, including cancer diseases such as lymphomas or leukemias.
10 cl, 10 dwg, 8 tbl, 10 ex
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Authors
Dates
2023-07-06—Published
2019-04-09—Filed