FIELD: biotechnology.
SUBSTANCE: present invention refers to immunology and biotechnology. There are presented embodiments of antibodies to C10orf54 or their antigen-binding fragments containing variable domains of heavy and light chains, each of which is characterized by presence of corresponding CDRs1-3. Described are: a coding antibody or its antigen-binding nucleic acid fragment, a recombinant expression vector thereof, comprising a host cell comprising such a vector and a method for producing the antibody using such a cell. Disclosed are an antibody-drug conjugate for inhibiting growth and/or destruction of C10orf54 expressing cells, and an antibody-based pharmaceutical composition, as well as use of a pharmaceutical composition for preventing and treating C10orf54-related symptoms and cancer. Also disclosed is a method of detecting C10orf54 in an antibody-based sample, as well as an antibody-based C10orf54-binding kit.
EFFECT: use of the invention provides antibodies which are capable of neutralizing C10orf54 activity, which can be used in preventing and/or treating cancer diseases associated with C10orf54.
14 cl, 30 dwg, 47 tbl, 9 ex
| Title | Year | Author | Number |
|---|---|---|---|
| ANTI-C10orf54 ANTIBODIES AND APPLICATIONS THEREOF | 2015 |
|
RU2819627C1 |
| CHIMERIC ANTIGENE RECEPTORS TARGETTING FLT3 | 2018 |
|
RU2820859C2 |
| RECOVERED ANTIBODY (VERSIONS), A METHOD FOR PRODUCING THE ANTIBODY, AN ISOLATED NUCLEIC ACID, AN EXPRESSION CASSETTE (VERSIONS), A PLASMID (VERSIONS), A HOST CELL, A PHARMACEUTICAL PREPARATION, A KIT, A METHOD OF TREATING A PATIENT, AT RISK OF OR SUFFERING FROM ESCHERICHIA COLI INFECTION, AND A DIAGNOSTIC TECHNIQUE FOR DETERMINING ESCHERICHIA COLI INFECTIONS | 2014 |
|
RU2724530C2 |
| ANTIBODY FOR SPECIFIC BINDING TO N-TERMINAL DOMAIN OF LYSYL-TRNA SYNTHETASE EXPOSED ON EXTRACELLULAR MEMBRANE | 2019 |
|
RU2781304C1 |
| CHIMERIC PROTEIN COMPOSED OF AN NGF ANTAGONIST DOMAIN AND A TNFΑ ANTAGONIST DOMAIN | 2015 |
|
RU2788122C2 |
| ANTIBODY AGAINST IL-5, ITS ANTIGEN-BINDING FRAGMENT AND ITS MEDICAL USE | 2018 |
|
RU2772716C2 |
| CONNECTIVE TISSUE GROWTH FACTOR ANTIBODY AND USE THEREOF | 2020 |
|
RU2819228C2 |
| BISPECIFIC PROTEIN | 2019 |
|
RU2784486C1 |
| ADVANCED PROCOAGULANT ANTIBODIES | 2019 |
|
RU2810748C2 |
| ANTIBODIES AGAINST HtrA1 AND METHODS OF THEIR APPLICATION | 2016 |
|
RU2750285C2 |
