FIELD: biotechnology.
SUBSTANCE: composition for generating an immune response against cytomegalovirus (CMV) is described. The composition contains live attenuated CMV, which is conditionally defective in replication, and contains (a) a pentameric gH complex, including UL128, UL130, UL131, gH and gL; and (b) a nucleic acid encoding a fusion protein consisting of an essential protein and a destabilizing protein, where the essential protein is selected from the group consisting of IE1/2, UL51, UL52, UL79 and UL84.
EFFECT: invention expands the arsenal of means for generating an immune response against cytomegalovirus.
43 cl, 30 dwg, 16 tbl, 15 ex
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