FIELD: biotechnology.
SUBSTANCE: composition for generating an immune response against cytomegalovirus (CMV) is described. The composition contains live attenuated CMV, which is conditionally defective in replication, and contains (a) a pentameric gH complex, including UL128, UL130, UL131, gH and gL; and (b) a nucleic acid encoding a fusion protein consisting of an essential protein and a destabilizing protein, where the essential protein is selected from the group consisting of IE1/2, UL51, UL52, UL79 and UL84.
EFFECT: invention expands the arsenal of means for generating an immune response against cytomegalovirus.
43 cl, 30 dwg, 16 tbl, 15 ex
| Title |
Year |
Author |
Number |
| PHARMACEUTICAL COMPOSITION CONTAINING ANTIBODIES TO PCSK-9, AND ITS USE |
2018 |
- Tian, Chenmin
- Li, Hao
- Liu, Xun
|
RU2782792C2 |
| PHARMACEUTICAL COMPOSITIONS FOR TREATING ACID SPHINGOMYELINASE DEFICIENCY |
2019 |
- Yang, Mark
- Buser, Claudia
- Perez-Ramirez, Bernardo
- Trierweiler, Grant
- Benjwal, Sangeeta
|
RU2826120C2 |
| INDUCIBLE CHIMERIC CYTOKINE RECEPTORS |
2019 |
- Nager, Endryu Ross
- Park, Spenser
- Chaparro Riggers, Khaver Fernando
- Lin, Redzhina Tszyunkhuej
- Van Blarkom, Tomas Dzhon
|
RU2826155C2 |
| PHARMACEUTICAL COMPOSITION CONTAINING ANTI-IL-5 ANTIBODY, AND USE THEREOF |
2020 |
- U, Tintin
- Li, Khao
- Lyu, Syun
- Tao, Vejkan
|
RU2824390C2 |
| COMBINED FORMULATIONS OF ANTI-LAG3 ANTIBODY AND ANTI-PD-1 ANTIBODY |
2019 |
- Antoshchuk, Valentin
- Desai, Priti, Dzh.
- Krishnamakhari, Jogita
- Sangani, Sakhil, S.
|
RU2822192C2 |
| STABLE FORMULATIONS OF ANTIBODIES TO HUMAN PROGRAMMED DEATH RECEPTOR PD-1 AND RELATED TREATMENT METHODS |
2012 |
- Sharma Manodzh K.
- Narasimkhan Chakravarti Nachu
- Gergich Kevin Dzhejms
- Kang Soonmo Piter
|
RU2563346C2 |
| LYOPHILISED DNA COMPOUNDS FOR INCREASED PLASMID DNA EXPRESSION |
2009 |
- Kim Dzong-Mook
- Kim Sudzeong
- Khan Voong
- Joo Vonsun
|
RU2470995C2 |
| PHARMACEUTICAL COMPOSITION OF THE FUSION PROTEIN OF THE TRANSFORMING GROWTH FACTOR BETA RECEPTOR AND ITS APPLICATION |
2019 |
- Tyan, Chenmin
- Li, Khao
- Lyu, Syun
|
RU2791683C2 |
| PHARMACEUTICAL COMPOSITION BASED ON ANTIBODIES AGAINST CD40 AND APPLICATION THEREOF |
2019 |
- Yang, Jianjian
- Li, Hao
- Liu, Xun
- Jiang, Jiahua
|
RU2778572C1 |
| STABLE COMPOSITIONS OF ANTI-TIGIT ANTIBODIES, INDIVIDUALLY AND IN COMBINATION WITH ANTIBODIES AGAINST PROGRAMMED DEATH RECEPTOR 1 (PD-1), AND METHODS OF THEIR USE |
2018 |
- De, Arnab
- Narasimkhan, Chakravarti Nachu
|
RU2820576C2 |
