RET INHIBITOR FOR USE IN THE TREATMENT OF CANCER WITH RET ALTERATION Russian patent published in 2023 - IPC A61K31/506 A61P35/00 

Abstract RU 2800951 C2

FIELD: medicine.

SUBSTANCE: group of inventions relates to the methods for treating cancer with an activating alteration rearranged during transfection (RET-altered cancer). Variants of a method of treating cancer having an activating transfection-rearranged alteration (RET-altered cancer) in a subject in need thereof are provided, comprising administering to the subject a therapeutically effective amount, 300 mg or 400 mg, of compound 1 or a pharmaceutically acceptable salt thereof once a day.

EFFECT: achievement of the maximum therapeutic effect while maintaining the safety of the medicinal product.

37 cl, 13 dwg, 2 tbl, 3 ex

Similar patents RU2800951C2

Title Year Author Number
RET INHIBITOR 2013
  • Kodama Tatsusi
  • Sakamoto Khirosi
  • Tsukaguti Tosiyuki
RU2648818C2
HUMAN RET-BINDING ANTIBODIES AND METHODS OF USE THEREOF 2020
  • Dejli, Kristofer
  • Terston, Gevin
  • Papadopulos, Nikolas
RU2821548C2
SUBSTITUTED AROMATIC DERIVATIVE WITH CONDENSED RINGS AND COMPOSITION INCLUDING IT AND THEIR USE 2020
  • Wang, Yihan
  • Xing, Qingfeng
  • Ai, Yixin
  • Li, Huanyin
RU2811484C1
THERAPEUTIC COMBINATIONS CONTAINING RAF INHIBITOR AND ERK INHIBITOR 2017
  • Caponigro, Giordano
  • Meyer, Matthew John
  • Cooke, Vesselina
  • Stuart, Darrin
RU2774612C2
COMBINATION THERAPY 2018
  • Cooke, Vesselina
RU2815400C2
HETEROCYCLIC COMPOUNDS AS RET KINASE INHIBITORS 2017
  • Jordan Allan
  • Newton Rebecca
  • Waszkowycz Bohdan
  • Sutton Jonathan Mark
  • Hynd George
  • Paoletta Silvia
  • Fordyce Euan Alexander Fraser
RU2742115C2
PHARMACEUTICAL COMBINATION CONTAINING TNO155 AND RIBOCICLIB 2020
  • Chen, Ying-Nan Pan
  • Hao, Huaixiang
  • Liu, Chen
  • Mohseni, Morvarid
RU2813111C2
CHIRAL DIARYL MACROCYCLES AND USE THEREOF 2016
  • Cui, Jingrong Jean
  • Li, Yishan
  • Rogers, Evan W.
  • Zhai, Dayong
  • Deng, Wei
  • Huang, Zhongdong
RU2728579C2
CRYSTALLINE FORM (S)-N-(5-((R)-2-(2,5-DIFLUOROPHENYL)-PYRROLIDIN-1-YL)-PYRAZOLO[1,5-A]PYRIMIDIN-3-YL)-3-HYDROXYPYRROLIDINE-1-CARBOXAMIDE HYDROSULPHATE 2015
  • Errigo Alisha B.
  • Dzhuengst Derrik
  • Shakh Khalid
RU2723990C2
METHODS OF TREATING CDK4/6 INHIBITOR-RESISTANT CANCER 2019
  • Patel, Khitisha
  • Bikhani, Tiru
  • Arlt, Khajke
  • Tao, Niandzhun
RU2820478C2

RU 2 800 951 C2

Authors

Evans Raab, Erica

Wolf, Beni B.

Dates

2023-08-01Published

2019-04-03Filed