SUBSTITUTED AROMATIC DERIVATIVE WITH CONDENSED RINGS AND COMPOSITION INCLUDING IT AND THEIR USE Russian patent published in 2024 - IPC C07D487/04 A61K31/41 A61K31/519 A61K31/5377 A61P35/00 A61P35/02 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula (II), where ring A represents isoxazolyl; R₁ represents -C(R_a1)(R_a2)(R_a3), where R_a1, R_a2 and R_a3 independently represent H, C_1-6 alkyl or C_1-6 haloalkyl; alternatively R_a1, R_a2 and R_a3 are independently C_1-4 alkyl or C_1-4 haloalkyl; alternatively R_a1, R_a2 and R_a3 are independently methyl or halomethyl; R₂ represents H; m is selected from 0, 1, 2 and 3; L₁ represents CH₂; R_Y is H or halogen, alternatively fluorine; Y₄ represents CH or N; Z₂ represents N or CR_Z2 where R_Z2 represents H; Z₃ represents N or C; Z₅ represents N, NR_Z5 or CR_Z5, where R_Z5 represents H; Z₆ represents NR_Z6 or CR_Z6, where R_Z6 represents C_1-6 alkyl; alternatively R_Z6 is C_1-4 alkyl; each of R_n1 and R_n2 is independently selected from H; or a pharmaceutically acceptable salt thereof; alternatively, wherein at most one of Z₅ and Z₆ represents a substituted or unsubstituted carbon atom. The invention relates to specific compounds (shown in the claims). The invention relates to a pharmaceutical composition used for inhibiting wild-type and mutant RET, KIF5B-RET, FLT3 and FLT3-ITD kinases, containing a therapeutically effective amount of a compound or a pharmaceutically acceptable salt thereof according to the invention and a pharmaceutically acceptable excipient.

(II)

EFFECT: aromatic derivative used in the production of a medicinal product for the treatment and/or prevention of a disease wherein the disease is mediated by protein kinases selected from wild type and mutant RET, KIF5B-RET, FLT3 and FLT3-ITD kinases.

28 cl, 6 dwg, 10 tbl, 13 ex