FIELD: biotechnology; medicine.
SUBSTANCE: monoclonal antibody or its antigen-binding fragment, which specifically binds to IL-4Rα (subunit of IL-4Rα interleukin receptor 4). The invention also relates to nucleic acids encoding the said antibody, expression vectors, host cells and methods of their production, methods of producing antibodies of the invention, pharmaceutical compositions containing an antibody of the invention, pharmaceutical compositions containing an antibody of the invention and other therapeutically active compounds, methods of treatment of IL-4Rα mediated diseases or disorders, uses of the antibodies or pharmaceutical compositions thereof for the treatment of IL-4Rα mediated diseases or disorders, and uses of the antibodies of the invention and other therapeutically active compounds for the treatment of IL-4Rα mediated diseases or disorders.
EFFECT: obtaining monoclonal antibody or its antigen-binding fragment which specifically binds to 4Rα (GD2 ganglioside).
41 cl, 8 dwg, 6 tbl, 12 ex
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