FIELD: medicine, oncology, and therapy.
SUBSTANCE: group of inventions is intended for the treatment of liver cancer. Talimogen lagerparepvec is used to treat a subject having liver cancer that hardly responds to standard systemic cancer therapy, progresses during standard systemic cancer therapy, and/or is resistant to standard systemic cancer therapy; talimogen lagerparepvec is administered to the subject in combination with pembrolizumab. Also the following is provided: the use of pembrolizumab for the treatment of a subject having liver cancer that hardly responds to standard systemic cancer therapy, progresses during standard systemic cancer therapy, and/or is resistant to standard systemic cancer therapy; pembrolizumab is administered to the subject in combination with the talimogen lagerparepvec. In other embodiments, the use of talimogen lagerparepvec and pembrolizumab in combination is provided for the treatment of a subject having liver cancer that hardly responds to standard systemic cancer therapy, progresses during standard systemic cancer therapy, and/or is resistant to standard systemic cancer therapy; the use of talimogen lagerparepvec for the treatment of a subject having liver cancer who has failed to achieve a sustained response after prior therapy with pembrolizumab, wherein talimogen lagerparepvec is administered to the subject in combination with pembrolizumab; the use of pembrolizumab for the treatment of a subject having liver cancer who has failed to achieve a sustained response following prior therapy with pembrolizumab, wherein pembrolizumab is administered to the subject in combination with the talimogen lagerparepvec; and the use of talimogen lagerparepvec and pembrolizumab in combination for the treatment of a subject with liver cancer who has failed to achieve a sustained response following prior pembrolizumab therapy.
EFFECT: use of the group of inventions makes it possible to increase the effectiveness of the treatment of liver cancer.
22 cl, 3 dwg, 1 tbl, 1 ex
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