CONTROL POINT INHIBITOR AND WHOLE-CELL MICROBACTERIA FOR USE IN TREATING ONCOLOGICAL DISEASE Russian patent published in 2020 - IPC A61K35/74 A61K39/04 A61K39/395 A61P35/00 

FIELD: medicine; oncology.

SUBSTANCE: group of inventions can be used for treating, reducing, inhibiting or controlling neoplasia, tumor or oncological disease in a subject. That is ensured by using non-pathogenic thermoinactivated Mycobacterium obuense in a patient for whom a therapy is provided by inhibiting immune control points simultaneously, separately or sequentially with administration of said Mycobacterium. Also disclosed is a method of treating, reducing, inhibiting or controlling neoplasia, tumor or oncological disease in a subject by simultaneous, separate or sequential administration to an ICRI agent, selected from a cell, protein, peptide, antibody or antigen-binding fragment thereof against CTLA-4, PD-1, PD-L1 and a combination thereof, and non-pathogenic thermoinactivated Mycobacterium obuense.

EFFECT: group of inventions enables higher effectiveness of treating tumors by synergetic effect.

30 cl, 1 dwg, 1 ex