PYRIDINE SULFONAMIDE COMPOUNDS FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH INTERLEUKIN 1 BETA Russian patent published in 2023 - IPC C07D401/04 C07D401/14 C07D405/04 C07D405/14 A61K31/497 A61K31/4545 A61P1/16 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to new compounds of pyridinesulfonamide formula I

where R¹ is phenyl or a 9-membered fused heteroaromatic ring system containing either 1 or 2 O heteroatoms optionally substituted with one substituent selected from the group consisting of C_1-4alkyl, C_1-4alkyl-Y¹-, C_1-4alkyl-Y¹ substituted with halogen, HO-C_1-4 alkanediyl; Y¹ is O; X¹ represents either NH or O; n1 is either 0 or 1; X³ is either absent or is NR^y; R^x and R^y are independently C_1-4alkyl; L is either O or CH₂; Z¹ and Z³ are selected from N and CH, Z² is CH; R³ is selected from the group consisting of halogen, C(O)NR^2aR^2b where R^2a and R^2b are independently selected from the group consisting of H and C_1-4alkyl; compositions comprising these compounds and use in the treatment of diseases mediated by IL-1β.

EFFECT: obtaining new compounds that can be used as drugs for the treatment of diseases sensitive to IL-1 inhibition, βsuch as non-alcoholic steatohepatitis (NASH) and idiopathic pulmonary fibrosis (IPF).

11 cl, 16 ex, 8 dwg