FIELD: pharmaceuticals.
SUBSTANCE: invention relates to new compounds of pyridinesulfonamide formula I
where R1 is phenyl or a 9-membered fused heteroaromatic ring system containing either 1 or 2 O heteroatoms optionally substituted with one substituent selected from the group consisting of C1-4alkyl, C1-4alkyl-Y1-, C1-4alkyl-Y1 substituted with halogen, HO-C1-4 alkanediyl; Y1 is O; X1 represents either NH or O; n1 is either 0 or 1; X3 is either absent or is NRy; Rx and Ry are independently C1-4alkyl; L is either O or CH2; Z1 and Z3 are selected from N and CH, Z2 is CH; R3 is selected from the group consisting of halogen, C(O)NR2aR2b where R2a and R2b are independently selected from the group consisting of H and C1-4alkyl; compositions comprising these compounds and use in the treatment of diseases mediated by IL-1β.
EFFECT: obtaining new compounds that can be used as drugs for the treatment of diseases sensitive to IL-1 inhibition, βsuch as non-alcoholic steatohepatitis (NASH) and idiopathic pulmonary fibrosis (IPF).
11 cl, 16 ex, 8 dwg
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