ANTHELMINTIC AZA-BENZOTHIOPHENE AND AZA-BENZOFURAN COMPOUNDS Russian patent published in 2025 - IPC C07D307/85 C07D407/12 C07D409/12 C07D413/14 C07D495/04 A61K31/343 A61K31/353 A61K31/381 A61K31/4365 A61K31/519 A61K31/537 A61P33/10 

FIELD: chemistry.

SUBSTANCE: group of inventions relates to organic chemistry and includes a compound of formula (I), pharmaceutically acceptable salts thereof, individual compounds specified in the claim, an anthelmintic veterinary composition containing them, and use thereof. In formula (I), L is L1 or L2, R¹ is C₁-C₆-alkyl, optionally substituted with 1–5 halogens or 1–3 hydroxyls, C₂-C₆-alkenyl, saturated or unsaturated 6-membered monocyclic heterocyclyl containing oxygen heteroatom, C₁-C₆-alkylcarbonyl, or -NR^aR^b, where R^a and R^b independently represent C₁-C₆-alkyl; or R^a and R^b can form, together with the nitrogen atom to which they are bonded, 6-member heterocyclyl group which can include an additional oxygen heteroatom; R² is a hydrogen atom; R³ is C₁-C₆-alkyl, optionally substituted with 1–3 halogen; C₃-C₆-cycloalkyl, optionally substituted with 1–3 halogen or C₁-C₄-halogenalkyl; C₃-C₆-cycloalkenyl, optionally substituted with 1–3 halogen or C₁-C₄-halogenalkyl; 3–7-membered monocyclic saturated or unsaturated heterocyclyl containing 1 or 2 heteroatoms of oxygen, sulphur or nitrogen, where the sulphur atom can be oxidised, optionally substituted with 1–3 C₁-C₆-alkyl; phenyl, optionally substituted with 1–3 halogen or C₁-C₆-alkyl; 6-member heteroaryl containing a heteroatom N, optionally substituted with halogen; spirocyclic carbocyclylcarbocyclyl group given in the claims; or -NR^aR^b, where R^a and R^b can form, together with the nitrogen atom to which they are bonded, 6-member heterocyclyl group, which can be optionally substituted with 1–2 halogen or C₁-C₃-alkyl groups; R⁴ in each case independently represents a hydrogen atom, or halogen; R⁵ in each case independently represents a hydrogen atom, or halogen; R¹⁰ is a hydrogen atom; X is S; Q is O; Y¹ is N; Y² and Y³ each independently represents -N- or -CR⁴-; Y^1' and Y^6' each represents C; Y^2', Y^3', Y^4', Y^5' each independently represents S, or -CR⁵-; W represents CR⁶R⁷, Z represents CR⁶R⁷ or O, where R⁶ and R⁷ represent a hydrogen atom; where maximum three of Y^1', Y^2', Y^3', Y^4', Y^5' and Y^6' are heteroatoms; is 0 or 1; q is 0 or 1; dotted bonds denote a single or double bond.

EFFECT: compounds of formula (I), which are active against animal parasites, such as Dirofilaria immitis or parasitic nematodes.

21 cl, 12 tbl, 4 ex