3'-DEAMINO-3'-(2"-PYRROLINE-1"-YL)-5-IMINO-13-DEOXYANTRACYCLINS AND PRODUCTION METHODS Russian patent published in 2023 - IPC C07H15/24 C07H15/252 A61K31/704 A61P35/00

Abstract RU 2803586 C2

FIELD: medicine.

SUBSTANCE: present invention relates to a compound of the formula

where R₁ is H; R₂ and R₃ are OH; R₄ is O-C_1-6alkyl; R₅ is NH, and R₆ is 2-pyrrolino-daunozamine or 2-pyrrolino-epidaunozamine, which is used for suppression of fibrosarcoma cell growth. The invention also relates to a pharmaceutical composition and to a synergetic combined preparation containing this compound, as well as to a method for suppression of fibrosarcoma cell growth.

EFFECT: provision of an anthracycline compound containing 2-pyrrolino-group, which increases anticancer activity, while saving a good safety profile.

20 cl, 4 tbl, 4 ex

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RU 2 803 586 C2

Authors

Olson, Richard

Walsh, Gerald

Dates

2023-09-18—Published

2018-02-16—Filed